Pregnancy Cat

Pregnancy Category D. Caution should be exercised when this drug is administered to a woman who is breastfeeding.

Precautions

This combination may aggravate peripheral arterial circulatory disorders. Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals.

Overdose Effects

No specific information is available with regard to overdosage of this combination in humans. Treatment should be symptomatic and supportive and directed to the removal of any unabsorbed drug by induced emesis, or administration of activated charcoal. Atenolol can be removed from the general circulation by hemodialysis. Further consideration should be given to dehydration, electrolyte imbalance and hypotension by established procedures.

Drug Classes

Combined antihypertensive preparations

Storage Conditions

Store in cool and dry place, protected from light.

Composition

n/a

Mode Of Action

Atenolol and chlorthalidone have been used singly and concomitantly for the treatment of hypertension. Studies have shown that there is no interference with bioavailability when these agents are given together in the single combination tablet. Therefore, this combination provides a convenient formulation for the concomitant administration of these two drugs. Atenolol is a beta1-selective (cardioselective) beta-adrenergic receptor blocking agent that provides-

reduction in resting and exercise heart rates and cardiac output
reduction of systolic and diastolic blood pressure at rest and on exercise
reduction in reflex orthostatic tachycardia.

Chlorthalidone is a monosulfonamyl diuretic with prolonged action and low toxicity. It produces diuresis with greatly increased excretion of sodium and chloride at distal convoluted tubule of the nephron.

Reconstitution

n/a