Pregnancy Cat

Pregnancy Category C. Avanafil is not indicated for use in women.

Precautions

Patients should not use Avanafil if sexual activity is inadvisable due to cardiovascular status or any other reason. Use of Avanafil with alpha-blockers, other antihypertensives, or substantial amounts of alcohol (greater than 3 units) may lead to hypotension.Patients should seek emergency treatment if an erection lasts greater than 4 hours.Patients should stop taking Avanafil and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign ofNon-Arteritic Ischemic Optic Neuropathy (NAION). Discuss with patients the increased risk of NAION in patients with a prior history of NAION.Patients should stop taking Avanafil and seek prompt medical attention in the event of sudden decrease or loss of hearing.

Overdose Effects

Single doses up to 800 mg have been given to healthy subjects, and multiple doses up to 300 mg have been given to patients. In cases of overdose, standard supportive measures should be adopted as required. Renal dialysis is not expected to accelerate clearance because avanafil is highly bound to plasma proteins and is not significantly eliminated in the urine.

Drug Classes

Drugs for Erectile Dysfunction

Storage Conditions

Store below 25°C temperature. Keep away from light and wet place. Keep out of reach of children.

Composition

n/a

Mode Of Action

Avanafil is a selective phosphodiesterase 5 (PDE5) enzyme inhibitor used for the treatment of erectile dysfunction caused by diabetes, age induced oxidative stress or other complications. Avanafil inhibits the cGMP specific phosphodiesterase 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penis erection during sexual stimulation is caused by increased penis blood flow resulting from the relaxation of penis arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase 5 (PDE5) by avanafil enhances erectile function by increasing the amount of cGMP.

Reconstitution

n/a