Pregnancy Cat

Magnesium Sulfate crosses the placenta. So, as with any other drugs, caution is required when the drug is administered to pregnant women. It is not known whether the drug is excreted in human milk. As it happens with many other drugs, cautions should be taken when it is administered to a nursing mother.

Precautions

Magnesium salts should be administered with caution to patients with impaired renal function or those receiving digitalis glycosides. Parenteral administration of magnesium salts may enhance the effect of neuromuscular blocking agents or of central nervous system depressants. Monitor blood pressure, respiratory rate, urinary output and for signs of over dosage like loss of patellar reflex, weakness, nausea, sensation of warmth, flushing of skin, drowsiness, double, vision and slurred speech.

Overdose Effects

Symptoms of hypermagnesemia are: respiratory depression and loss of deep tendon reflexes due to neuromuscular blockade, nausea, vomiting, flushing, thirst, hypotension, drowsiness, confusion, slurred speech, double vision, bradycardia and muscle weakness.

Drug Classes

Specific mineral preparations

Storage Conditions

Store in a cool & dry place, keep away from light & children.

Composition

Magnesium is an essential constituent of many enzyme systems, particularly those involved in energy generation; the largest stores are in the skeleton.

Each 5 ml ampoule of injection contains 50% solution of Magnesium sulphate heptahydrate BP (Mg2+ approx. 2 mmol/ml), total 2.47gm.
Each 100 ml bottle of infusion contains 4% solution of Magnesium sulphate heptahydrate BP (Mg2+ approx. 0.16 mmol/ml), total 4 gm.

Mode Of Action

Magnesium is the second most plentiful cation of intracellular fluids. It is essential for the activity of many enzyme systems and plays an important role with regard to neurochemical transmission and muscular excitability. Deficits are accompanied by a variety of structural and functional disturbances.

Reconstitution

n/a