Indications

Deferiprone is indicated for the treatment of iron overload patients with thalassemia major when deferoxamine therapy is contraindicated or inadequate. Deferiprone therapy should be initiated and maintained by a physician experienced in the treatment of patients with thalassemia.

Interaction

The safety of concurrent use of Deferiprone and Vitamin C has not been formally studied. Based on the reported adverse interaction that can occur between deferoxamine and Vitamin C, caution should be used when administering concurrent Deferiprone and Vitamin C. It should not be given with aluminium containing antacids.

Contraindications

It is contraindicated for hypersensitivity to the active substance or any of the excipients.

Side Effects

Gastrointestinal disorders such as diarrhoea, nausea, vomiting and abdominal pain are common during deferiprone treatment and may require temporary reduction in dose. A reddish brown discoloration of the urine is also common. Other adverse effects that have been reported include arthralgia and increased liver enzymes.