Indications

Amisulpride is indicated for the treatment of acute and chronic schizophrenic disorders, in which positive symptoms (such as delusions, hallucinations, and thought disorders) and/or negative symptoms (such as blunted affect, emotional and social withdrawal) are prominent, including patients characterized by predominant negative symptoms.

Interaction

With medicine: Consumption of alcohol while taking this medicine can cause CNS depression characterized by confusion, lack of focus, anxiety, drowsiness etc. As the risk of adverse effects are increasingly high uptake of alcohol along with Amisulpride, so uptake of alcohol while taking this medicine should be avoided. Drug Interaction may occur with Diltiazem, Pregabalin, Tramadol, Amiodarone, Quinidine, Bromocriptine, Ropinirole. Concomitant use of amisulpride with other anti-psychotics may increase the risk of developing neuroleptic malignant syndrome. Co-administration of amisulpride and clozapine may lead to an increase in plasma levels of Amisulpride. Amisulpride may enhance the effects of the following medicines:

CNS depressants including narcotics, anaesthetics, analgesics, sedative H1 antihistamines, barbiturates, benzodiazepines and other anxiolytic medicines, clonidine and derivatives.
Antihypertensive medicines and other hypotensive medications.

With food and others: Can be taken with or without food causes no interaction.

Contraindications

Amisulpride is contraindicated if hypersensitivity to the active ingredient or to other ingredients of the drug occurs. Concomitant prolactin-dependent tumours, e.g. pituitary gland prolactinomas and breast cancer. It is also contraindicated in pheochromocytoma, children up to puberty, pregnancy & lactation. In combination with the following medication:

Class-I anti-arrhythmic agents such as quinidine and disopyramide
Class-II anti-arrhythmic agents such as amiodarone and sotalol
Other medications such as bepridil, cisapride, sultopride, thioridazine, metha done, intravenous erythromycin intravenous vincamine, halofantrine, pentamidine, sparfloxacin & levodopa. In hepatic impairment amisulpride may be contraindicated to avoid the possible risk of adverse events due to an influence of the disease on amisulpride metabolism.

Side Effects

Common: Trembling, muscle stiffness or spasm, slow movement, producing more saliva than usual or feeling restless. Movements that patient cannot control, mainly of the head, neck, jaw or eyes. Difficulty sleeping (insomnia) or feeling anxious or agitated, feeling drowsy or sleepy, constipation, feeling or being sick, dry mouth, putting on weight, low blood pressure, dizziness, difficulty reaching orgasm, blurred vision, Increased blood levels of prolactin.Rare: Movements that you cannot control, mainly of the face or tongue, Osteoporosis (condition, when your bones are more likely to break) or osteopenia (bone weakening), aspiration pneumonia (a type of lung infection that occurs when food, saliva, liquids, or vomit is breathed into the lungs or airways leading to the lungs, instead of being swallowed into the esophagus and stomach.