Pregnancy Cat

Pregnancy Category C. There are no adequate and well controlled studies in pregnant women. Dapsone has been shown to have an embryocidal effect in rats and rabbits. These effects were probably secondary to maternal toxicity. Dapsone Gel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Although systemic absorption of dapsone following topical application Dapsone Gel is minimal relative to oral dapsone administration, it is known that dapsone is excreted in human milk. Because of the potential for oral dapsone to cause adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue Dapsone Gel, taking into account the importance of the drug to the mother.

Precautions

Methemoglobinemia: Cases of Methemoglobinemia have been reported. Discontinue Dapsone Gel if signs of Methemoglobinemia occur.Hematologic Effects: Some subjects with Glucose Phosphate Dehydrogenase (G6PD) deficiency using Dapsone Gel developed laboratory changes suggestive of hemolysis.

Overdose Effects

n/a

Drug Classes

Acne treatment preparations

Storage Conditions

Store at or below 30°C temperature. Keep away from light and wet place. Keep out of reach of children.

Composition

n/a

Mode Of Action

Dapsone has both anti-infammatory and antimicrobial properties. A combination of these activities may account for its efcacy in acne. Anti-infammatory efects include inhibition of neutrophil myeloperoxidase and eosinophil peroxidase activity, suppression of hypochlorous acid production, scavenging of reactive oxygen species, suppression of neutrophil activity, and inhibition of chemoattractant-induced signal transduction. Antimicrobial activity, similar to that of sulfones and sulfonamides, is by inhibition of bacterial dihydropteroate synthase in the folic acid metabolic pathway. This mechanism is efective against microorganisms synthesizing their own folic acid. In vitro susceptibility testing has demonstrated some activity for Dapsone against Propionibacterium species, including Propionibacterium acnes (P. acnes).

Reconstitution

n/a